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Instead, these studies are monitored entirely by an Institutional Review Board . It is not a substitute for professional mesothelioma final weeks medical advice, diagnosis or treatment. Any unauthorized or illegal use, copying or dissemination will be prosecuted.

mesothelioma clinical trial

Patients may also find grant programs or other options to help cover additional costs of participating in a clinical trial. In a clinical trial, participants are assigned to a specific treatment group. A placebo is a “fake” treatment designed to appear identical to the treatment being studied. Placebos help prevent doctors and patients from knowing which treatment each patient received. This helps ensure any results are due to the treatment, not a patient’s perception of it. Such resources often list the status of the clinical trial for patients to identify if they’re recruiting, in progress or closed.

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If an individual believes they qualify for a trial, they should discuss it with their oncologist. Contact information for the study organizers is included in the trial’s record on ClinicalTrials.gov. The Federal Government and an Institutional mesothelioma tumor Review Board enforce the regulations. These stringent rules are intended to keep the risks of the study as low as possible. Clinical trials are highly regulated in order to ensure patient safety as well as the integrity of results.

mesothelioma clinical trial

If an experimental therapy isn’t working, physicians will discuss other options with their patients. This is a study of ADI-PEG 20 , an arginine degrading enzyme versus placebo in patients with malignant pleural mesothelioma with low argininosuccinate mesothelioma clinical trial synthetase 1 expression. Malignant pleural mesothelioma have been found to require arginine, an amino acid. Thus the hypothesis is that by restricting arginine with ADI-PEG 20, the malignant pleural mesothelioma cells will starve and die.

Learn More About Clinical Trials

Mesothelioma Hope was founded by a team of advocates to educate people about this aggressive form of cancer. This trial was expected to start in September 2020 but has not begun accepting patients. Those interested can contact the Dana-Farber Cancer Institute for more information. Sexually active men and women of childbearing potential who are not willing to use an effective contraceptive method during the trial and up to 120 days following cessation of trial treatment. Known unstable or unresolved surgical or chemotherapy-related toxicity that would compromise the patient’s capacity to participate in the trial.

Mesothelioma therefore represents a growing health burden, but it remains under-researched and treatment options are limited. Chemotherapy is currently the standard of care in the first-line setting in which two positive, randomised phase III trials have been reported, showing improved survival with the addition of pemetrexed or raltitrexed to cisplatin, respectively . The recent French MAPS trial has shown that the addition of bevacizumab to pemetrexed-cisplatin and bevacizumab maintenance, improves survival from 16.1 months within the control arm to 18.8 months with the addition of bevacizumab . One such avenue may be to target the epigenetic machinery to elicit such responses sometimes described as immunoprobing .

mesothelioma clinical trial

CONFIRM is being run in approximately 25 UK centres with the aim of recruiting a total of 336 patients. Jodi has been a survivor of pleural mesothelioma for over multiple decades. It’s important veterans and mesothelioma to note that the informed consent form is not a binding contract. You can leave the trial for any reason at any time and don’t need to disclose your reasons to the research team.

Check out the National Cancer Institute website for a list of current trials investigating new mesothelioma treatments. These are some of the important surviving mesothelioma and other cancers a patient’s guides completed or ongoing. While participating in clinical trials to help further medical knowledge is altruistic, it is not realistic. The real motivation for participation is to benefit from a novel treatment or intervention. This is especially important for patients with an incurable disease, like late-stage mesothelioma.

mesothelioma clinical trial

This may include that the new treatment is not working or there are serious side effects. Clinical trials are also closely monitored by experts who watch for any problems with each study. People who participate in clinical trials can be some of the first to get a treatment before it is available to the public. But there are some risks with a clinical trial, including possible side effects and the chance that the new treatment may not work. People are encouraged to talk with their health care team about the pros and cons of joining a specific study.

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